KEGG   Cryptosporidium hominis: Chro.40506
Entry
Chro.40506        CDS       T00210                                 
Name
(RefSeq) chain A, crystal structure of Dhfr
  KO
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Organism
cho  Cryptosporidium hominis
Pathway
cho00240  Pyrimidine metabolism
cho00670  One carbon pool by folate
cho00790  Folate biosynthesis
cho01100  Metabolic pathways
cho01232  Nucleotide metabolism
cho01240  Biosynthesis of cofactors
Module
cho_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:cho00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    Chro.40506
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    Chro.40506
   00670 One carbon pool by folate
    Chro.40506
Enzymes [BR:cho01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     Chro.40506
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     Chro.40506
SSDB
Motif
Pfam: Thymidylat_synt DHFR_1
Other DBs
NCBI-GeneID: 3413852
NCBI-ProteinID: XP_665866
Position
4
AA seq 521 aa
MSEKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWD
SIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYR
DALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEK
KTLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQY
LDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIK
GDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDY
TGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNL
YQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRT
PRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV
NT seq 1566 nt   +upstreamnt  +downstreamnt
atgagtgaaaagaacgtttcaattgttgtggcagcttctgttttgagcagtgggatagga
attaacggacaattaccttggtctatatctgaggatttgaaatttttttcaaagataact
aataataaatgtgactcgaataagaagaatgcactaattatgggaagaaaaacatgggat
tcaattggaagaagacctcttaaaaatagaataattgtcgttatttcctccagcttacca
caagatgaagccgatcctaatgttgttgtatttagaaaccttgaagactcaatagagaat
cttatgaatgatgactcaattgagaatattttcgtctgtggtggtgaatccatatacagg
gatgctttaaaggataactttgtagatagaatatacttaacaagggtggcactagaagat
atagaatttgacacttatttcccagaaatacctgagacattcttaccagtatatatgtct
cagacattctgtactaagaatatctcttatgattttatgatttttgaaaaacaagaaaaa
aaaactttacaaaattgtgaccctgccagaggtcaattaaagtccattgatgatacagtt
gatcttcttggtgaaatatttgggattagaaaaatgggaaatagacacaagtttccaaaa
gaagaaatctacaacactccaagtattcgattcggaagagaacattatgagtttcagtac
ctggaccttctttctagggtcttagagaatggagcttatagggaaaataggacaggcatt
agtacatattcaatatttggtcagatgatgagatttgatatgagagaatcttttccactt
ttgactacaaaaaaagttgcaatcagatccatttttgaggagttaatatggtttattaag
ggagatactaatggaaatcatttgattgagaaaaaagtttatatttggtcaggaaatggc
tcgaaagaatatttggaaagaattggtttagggcatagagaggagaatgatttgggcccg
atctatggttttcagtggagacattacaatggagagtacaaaacgatgcatgacgattat
accggagttggagttgatcagcttgcaaaacttattgagaccctaaagaataacccaaag
gatagaaggcatatactaacagcctggaatccatctgccctatctcaaatggctcttccg
ccttgccatgtgctttctcagtattatgttaccaatgataattgtcttagttgcaacctt
tatcaaaggagttgtgacttgggattaggatctccatttaacattgcatcttatgctata
cttaccatgatgcttgctcaagtttgtggttatgaaccaggtgagcttgctatttttatt
ggagatgcccatatctatgaaaatcacctaacacaattaaaagaacaattaagccgcact
ccacgtccatttccacaactcaaattcaaaagaaaagttgaaaatattgaagactttaaa
tgggaagacatcgaattaatcggatattatccatatcccactattaaaatggacatggcg
gtataa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (9)   
   KEGG PATHWAY (6)   
   KEGG MODULE (3)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (9)   
   KEGG ENZYME (2)   
   KEGG REACTION (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (2)   
   Pfam (2)   
All databases (40)   

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